Protein Design: From the Aspect of Water Solubility and Stability.

ABSTRACT: Water solubility and structural stability are key merits for proteins defined by the primary sequence and 3D-conformation. Their manipulation represents important aspects of the protein design field that relies on the accurate placement of amino acids and molecular interactions, guided by underlying physiochemical principles. Emulated designer proteins with well-defined properties both fuel the knowledge-base for more precise computational design models and are used in various biomedical and nanotechnological applications. The continuous developments in protein science, increasing computing power, new algorithms, and characterization techniques provide sophisticated toolkits for solubility design beyond guess work. In this review, we summarize recent advances in the protein design field wi

SUBMITTER: Qing R 

PROVIDER: S-EPMC9523718 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature