Highly sensitive benzothiazole-based chemosensors for detection and bioimaging of peroxynitrite in living cells.

ABSTRACT: It is well accepted that peroxynitrite (ONOO^-) plays a crucial role in various physiological and pathological processes. Thus, the detection and imaging of ONOO^- in vitro and in vivo with high selectivity and sensitivity is of great significance. Here we report two simple benzothiazole-based fluorescent chemosensors, BS1 and BS2. Under physiological pH, both probes could quickly sense ONOO^- with a remarkable "turn-on" fluorescence signal at 430 nm. The limit of detection (LOD) of BS1 and BS2 toward ONOO^- was 12.8 nM and 25.2 nM, respectively, much lower than the reported values. Experimental results indicated that BS1 with a diphenyl phosphonate unit presented higher selectivity for ONOO^- than BS2. Furthermore, based on t

SUBMITTER: Kong Y 

PROVIDER: S-EPMC9523762 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature