Analysis of adaptive platform trials using a network approach.

ABSTRACT:

Background

Adaptive platform trials allow randomized controlled comparisons of multiple treatments using a common infrastructure and the flexibility to adapt key design features during the study. Nonetheless, they have been criticized due to the potential for time trends in the underlying risk level of the population. Such time trends lead to confounding between design features and risk level, which may introduce bias favoring one or more treatments. This is particularly true when experimental treatments are not all randomized during the same time period as the control, leading to the potential for bias from non-concurrent controls.

Methods

Two analysis methods addressing this bias are stratification and adjustment. Stratification uses only comparisons between treatment coho

SUBMITTER: Marschner IC 

PROVIDER: S-EPMC9523818 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature