'FLARE' of tumor marker in advanced gastric cancer treated with first-line systemic therapy.

ABSTRACT:

Background

Transient tumor marker elevations caused by chemotherapy were defined as 'Flare' and have been demonstrated in some solid tumors. In clinical practice, we observed that some patients were accompanied by elevated tumor markers during treatment, but subsequent imaging proved that the treatment they received was effective.

Objectives

We aimed to study the Flare and the prognosis in advanced gastric cancer.

Design

This is an observational retrospective study. A total of 167 patients were enrolled in this study. Carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 19-9 and CA125 values were obtained before the first, second, third, fourth, fifth and sixth cycles of treatment, respectively.

Methods

Imaging for the first efficacy assessment was reviewe

SUBMITTER: Zhang F 

PROVIDER: S-EPMC9523829 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature