Immune-related 3-lncRNA signature with prognostic connotation in a multi-cancer setting.

ABSTRACT:

Background

Advances in our understanding of the tumor microenvironment have radically changed the cancer field, highlighting the emerging need for biomarkers of an active, favorable tumor immune phenotype to aid treatment stratification and clinical prognostication. Numerous immune-related gene signatures have been defined; however, their prognostic value is often limited to one or few cancer types. Moreover, the area of non-coding RNA as biomarkers remains largely unexplored although their number and biological roles are rapidly expanding.

Methods

We developed a multi-step process to identify immune-related long non-coding RNA signatures with prognostic connotation in multiple TCGA solid cancer datasets.

Results

Using the breast cancer dataset as a discovery cohort w

SUBMITTER: Sherif S 

PROVIDER: S-EPMC9523969 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature