Circulating and urinary microRNAs profile for predicting renal recovery from severe acute kidney injury

ABSTRACT:

Background

There is little known about the contribution of microRNAs (miRNAs) in the recovery from acute kidney injury (AKI). This study aimed to discover and validate miRNA profiles for predicting renal recovery from severe AKI.

Patients and methods

A prospective observational study was conducted between June 2020 and January 2021. Urine and serum samples of participants with AKI stage 3 were collected from two groups: renal recovery and renal non-recovery. Transcriptomic analysis was performed using nCounter miRNA Expression Assay. Expression levels of candidate miRNAs were validated using quantitative real-time polymerase chain reaction (qRT-PCR).

Results

The discovery phase identified 18 and 11 differentially expressed miRNAs that were statistically significa

SUBMITTER: Phulkerd T 

PROVIDER: S-EPMC9523985 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature