Aberrant dynamic minimal spanning tree parameters within default mode network in patients with autism spectrum disorder.

ABSTRACT: The altered functional connectivity (FC) level and its temporal characteristics within certain cortical networks, such as the default mode network (DMN), could provide a possible explanatory framework for Autism spectrum disorder (ASD). In the current study, we hypothesized that the topographical organization along with its temporal dynamics of the autistic brain measured by temporal mean and variance of complex network measures, respectively, were significantly altered, which may further explain the autistic symptom severity in patients with ASD. To validate these hypotheses, the precise FCs between DMN regions at each time point were calculated using the resting-state functional magnetic resonance imaging (fMRI) datasets from the Autism Brain Imaging Data Exchange (ABIDE) project. Then,

SUBMITTER: Jia H 

PROVIDER: S-EPMC9524021 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature