Assessing the causal association between human blood metabolites and the risk of epilepsy.

ABSTRACT:

Background

Metabolic disturbance has been reported in patients with epilepsy. Still, the evidence about the causal role of metabolites in facilitating or preventing epilepsy is lacking. Systematically investigating the causality between blood metabolites and epilepsy would help provide novel targets for epilepsy screening and prevention.

Methods

We conducted two-sample Mendelian randomization (MR) analysis. Data for 486 human blood metabolites came from a genome-wide association study (GWAS) comprising 7824 participants. GWAS data for epilepsy were obtained from the International League Against Epilepsy (ILAE) consortium for primary analysis and the FinnGen consortium for replication and meta-analysis. Sensitivity analyses were conducted to evaluate heterogeneity and pleiotr

SUBMITTER: Cai J 

PROVIDER: S-EPMC9524049 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature