Construction and yield optimization of a cinnamylamine biosynthesis route in Escherichia coli.

ABSTRACT:

Background

With the development of metabolic engineering and synthetic biology, the biosynthesis of aromatic compounds has attracted much attention. Cinnamylamine is an aromatic compound derived from L-phenylalanine, which is used in the synthesis of biologically active molecules, including drugs, and energetic materials. Cinnamylamine has been mainly synthesized by chemical methods to date, and few reports have focused on the biosynthesis of cinnamylamine. Therefore, it is desirable to establish an efficient biosynthesis method for cinnamylamine.

Results

The ω-aminotransferase Cv-ωTA from Chromobacterium violaceum has been demonstrated to have high enzyme activity in the conversion of cinnamaldehyde to cinnamylamine. To prevent the preferable conversion of cinnamaldehyde to

SUBMITTER: Wang Q 

PROVIDER: S-EPMC9524069 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature