Gestational hypoxia in late pregnancy differentially programs subcortical brain maturation in male and female rat offspring.

ABSTRACT:

Background

Hypoxia is associated with pregnancy complications, such as preeclampsia, placental abruption, and gestational sleep apnea. Hypoxic insults during gestation can impact the brain maturation of cortical and subcortical pathways, such as the nigrostriatal pathway. However, the long-term effects of in utero hypoxic stress exposure on brain maturation in offspring are unclear, especially exposure during late gestation. The purpose of this study was to determine the impact of gestational hypoxia in late pregnancy on developmental programming of subcortical brain maturation by focusing on the nigrostriatal pathway.

Methods

Timed pregnant Long-Evans rats were exposed to chronic intermittent hypoxia or room air normoxia from gestational day (GD) 15-19 (term 22-23 days). Ma

SUBMITTER: Wilson EN 

PROVIDER: S-EPMC9524087 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature