Nanoengineering facilitating the target mission: targeted extracellular vesicles delivery systems design.

ABSTRACT: Precision medicine has put forward the proposition of "precision targeting" for modern drug delivery systems. Inspired by techniques from biology, pharmaceutical sciences, and nanoengineering, numerous targeted drug delivery systems have been developed in recent decades. But the large-scale applications of these systems are limited due to unsatisfactory targeting efficiency, cytotoxicity, easy removability, and instability. As such, the natural endogenous cargo delivery vehicle-extracellular vesicles (EVs)-have sparked significant interest for its unique inherent targeting properties, biocompatibility, transmembrane ability, and circulatory stability. The membranes of EVs are enriched for receptors or ligands that interact with target cells, which endows them with inherent targeting missio

SUBMITTER: Song H 

PROVIDER: S-EPMC9524104 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature