LAG3 blockade coordinates with microwave ablation to promote CD8⁺ T cell-mediated anti-tumor immunity.

ABSTRACT:

Background

The immune checkpoint inhibitors (ICIs) combined with other therapeutic strategies have shown exciting results in various malignancies, and ICIs have now become the gold standard for current cancer treatment. In several preclinical and clinical investigations, ablation coupled with immunotherapy has proved to be quite effective. Our previous studies have shown that ablation coupled with ICI is a potential anti-cancer regimen for colorectal cancer liver metastases (CRLM). Furthermore, we have reported that following microwave ablation (MWA), the expression of LAG3 is up-regulated in tumor microenvironment (TME), indicating that LAG3 is implicated in the regulation of immunosuppressive immune response, and combination therapy of MWA and LAG3 blockade can serve as a promisi

SUBMITTER: Shao D 

PROVIDER: S-EPMC9524118 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature