Gastrointestinal adverse events of metformin treatment in patients with type 2 diabetes mellitus: A systematic review, meta-analysis and meta-regression of randomized controlled trials.

ABSTRACT:

Introduction

Metformin is the first choice drug in the treatment of type 2 diabetes mellitus but its administration may be linked to gastrointestinal adverse events limiting its use.

Objectives

The objective of this systematic review and meta-analysis was to assess the risk of gastrointestinal adverse events related to metformin use in patients with type 2 diabetes treated with metformin.

Methods

PUB MED/CINAHL/Web of Science/Scopus were searched from database inception until 08.11.2020 for articles in English and randomized controlled trials related to patients with type 2 diabetes treated with metformin were included.

Results

From 5315 publications, we identified 199 potentially eligible full-text articles. Finally, 71 randomized controlled trials were includ

SUBMITTER: Nabrdalik K 

PROVIDER: S-EPMC9524196 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature