Association of HOTAIR rs1899663 G>T Polymorphism with Colorectal Cancer in the Turkish Population: A Case-Control Study.

ABSTRACT:

Background

Long noncoding RNAs increase the overexpression of oncogenes. Cancer development and metastasis of cancer may occur as a result of overexpression of oncogenes. Polymorphisms in the genes (such as HOTAIR, etc.) in which long noncoding RNAs are synthesized affect the expression of these genes. Therefore, these polymorphisms may play a role in cancer development and cancer metastasis. The present study aimed to evaluate the association between HOTAIR gene rs1899663 G>T polymorphism with colorectal cancer.

Methods

The current study examined the HOTAIR gene rs1899663 G>T polymorphism in 100 patients with colorectal cancer and 93 healthy persons by a real-time polymerase chain reaction.

Results

The G and T allele frequencies of the HOTAIR rs1899663 polymorphism w

SUBMITTER: Yalınbas Kaya B 

PROVIDER: S-EPMC9524440 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature