Hepatoblastomas with carcinoma features represent a biological spectrum of aggressive neoplasms in children and young adults.

ABSTRACT:

Background & aims

Hepatoblastoma (HB) and hepatocellular carcinoma (HCC) are the predominant liver cancers in children, though their respective treatment options and associated outcomes differ dramatically. Risk stratification using a combination of clinical, histological, and molecular parameters can improve treatment selection, but it is particularly challenging for tumors with mixed histological features, including those in the recently created hepatocellular neoplasm not otherwise specified (HCN NOS) provisional category. We aimed to perform the first molecular characterization of clinically annotated cases of HCN NOS.

Methods

We tested whether these histological features are associated with genetic alterations, cancer gene dysregulation, and outcomes. Namely, we compare

SUBMITTER: Sumazin P 

PROVIDER: S-EPMC9524481 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature