Neural circuits mediating circulating interleukin-1β-evoked fever in the absence of prostaglandin E2 production.

ABSTRACT: Infectious diseases and inflammatory conditions recruit the immune system to mount an appropriate acute response that includes the production of cytokines. Cytokines evoke neurally-mediated responses to fight pathogens, such as the recruitment of thermoeffectors, thereby increasing body temperature and leading to fever. Studies suggest that the cytokine interleukin-1β (IL-1β) depends upon cyclooxygenase (COX)-mediated prostaglandin E₂ production for the induction of neural mechanisms to elicit fever. However, COX inhibitors do not eliminate IL-1β-induced fever, thus suggesting that COX-dependent and COX-independent mechanisms are recruited for increasing body temperature after peripheral administration of IL-1β. In the present study, we aimed to build a foundation for the neural

SUBMITTER: Mota CMD 

PROVIDER: S-EPMC9524517 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature