Association of androgen receptor expression with glucose metabolic features in triple-negative breast cancer.

ABSTRACT:

Background

Androgen receptor (AR) is a potential therapeutic target in triple-negative breast cancer (TNBC). We aimed to elucidate the association of AR expression with glucose metabolic features in TNBC.

Methods

Two independent datasets were analyzed: FDG PET data of our institution and a public dataset of GSE135565. In PET analysis, patients with TNBC who underwent pretreatment PET between Jan 2013 and Dec 2017 were retrospectively enrolled. Clinicopathologic features and maximum standardized uptake value (SUVmax) of tumors were compared with AR expression. In GSE135565 dataset, glycolysis score was calculated by the pattern of glycolysis-related genes, and of which association with SUVmax and AR gene expression were analyzed.

Results

A total of 608 female patients

SUBMITTER: Lee R 

PROVIDER: S-EPMC9524647 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature