A change of PD-1/PD-L1 expression on peripheral T cell subsets correlates with the different stages of Alzheimer's Disease.

ABSTRACT:

Background

Immune checkpoints are a set of costimulatory and inhibitory molecules that maintain self-tolerance and regulate immune homeostasis. The expression of immune checkpoints on T cells in malignancy, chronic inflammation, and neurodegenerative diseases has gained increasing attention.

Results

To characterize immune checkpoints in neurodegenerative diseases, we aimed to examine the expression of the immune checkpoint PD-1/PD-L1 in peripheral T cells in different Alzheimer's disease (AD) patients. To achieve this aim, sixteen AD patients and sixteen age-matched healthy volunteers were enrolled to analyze their CD3⁺ T cells, CD3⁺CD56⁺ (neural cell adhesion molecule, NCAM) T cells, CD4⁺/CD8⁺ T cells, and CD4⁺

SUBMITTER: Wu CT 

PROVIDER: S-EPMC9524741 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature