Contribution of Impaired DNASE1L3 Activity to Anti-DNA Autoantibody Production in Systemic Lupus Erythematosus.
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SUBMITTER: Mathapathi S
PROVIDER: S-EPMC9524810 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
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Contribution of Impaired DNASE1L3 Activity to Anti-DNA Autoantibody Production in Systemic Lupus Erythematosus.
Mathapathi Samarth S Chu Cong-Qiu CQ
Rheumatology and immunology research 20220301 1
Anti-DNA autoantibodies are pathogenic in systemic lupus erythematosus (SLE). Cell-free chromatin associated long DNA fragments are antigens for anti-DNA antibodies. In health state, released by cell death and actively secreted by live cells, these cell-free DNA are cleared by deoxyribonucleases (DNASES). In SLE, cell-free DNA are accumulated. The defective clearance of long fragments of cell-free DNA in SLE is largely attributed to impaired deoxyribonuclease 1 like 3 (DNASE1L3). <i>DNASE1L3</i> ...[more]
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