Integrative analysis of the characteristic of lipid metabolism-related genes for the prognostic prediction of hepatocellular carcinoma.

ABSTRACT:

Background

Dysregulation of lipid metabolism is implicated in the progression of hepatocellular carcinoma (HCC). We therefore investigated the molecular characteristics of lipid-metabolism-related genes in HCC.

Methods

Multi-dimensional bioinformatics analysis was conducted to comprehensively identify the lipid metabolism-related genes (LMRGs) from public databases, as well as the clinical information, immune features, and biological characteristics of HCC. The IMGR were then used to classify HCC into molecular phenotypes. Six lipid metabolism-related genes sets with the potential to predict the prognosis of HCC patients were identified.

Results

A total of 770 HCC patients with complete clinical information and corresponding 776 LMRGs were downloaded from 3 databases.

SUBMITTER: Zhu P 

PROVIDER: S-EPMC9524878 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature