Diversity of the gut, vaginal and oral microbiome among pregnant women in South Africa with and without pre-eclampsia.

ABSTRACT:

Background

Changes in microbial communities are a known characteristic of various inflammatory diseases and have been linked to adverse pregnancy outcomes, such as preterm birth. However, there is a paucity of information regarding the taxonomic composition and/or diversity of microbial communities in pre-eclampsia. The aim of this study was to determine the diversity of the gut, vaginal and oral microbiome in a cohort of South African pregnant women with and without pre-eclampsia. The diversity of the gut, vaginal and oral microbiome was determined by targeted next generation sequencing (NGS) of the V3 and V4 region of the 16S rRNA gene on the Illumina MiSeq platform.

Results

In this study population, pre-eclampsia was associated with a significantly higher alpha diversity

SUBMITTER: Geldenhuys J 

PROVIDER: S-EPMC9525020 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature