Ontology highlight
ABSTRACT: Background
In Southeast-Asia, where many conditions associated with dissemination of ESBL-producing Enterobacterales (ESBL-E) in the community are met, data from the community are scarce but show high ESBL-E carriage prevalence. Maternal ESBL-E colonization is considered a risk factor for neonatal colonization, which is the first step towards developing neonatal sepsis. Despite this, ESBL-E carriage prevalence and its risk factors during pregnancy or postpartum remain undefined in Southeast-Asia.Objectives
To estimate the prevalence of ESBL-E faecal colonization among peripartum women in the community of an urban and a rural area in Cambodia, to investigate ESBL-E genomic characteristics and to identify associated risk factors.Methods
Epidemiological data and faecal samples from 423 peripartum women were collected in an urban and rural areas in Cambodia (2015-16). Bacterial cultures, antibiotic susceptibility tests and ESBL gene sequencing were performed. Risk factor analysis was conducted using logistic regression.Results
The prevalence of ESBL-E faecal carriage was 79.2% (95% CI 75.0%-82.8%) among which Escherichia coli (n = 315/335, 94.0%) were most frequent. All isolates were multidrug resistant. Among 318 ESBL-E, the genes most frequently detected were blaCTX-M-15 (41.5%), blaCTX-M-55 (24.8%), and blaCTX-M-27 (15.1%). Low income, undernutrition, multiparity, regular consumption of pork, dried meat, and raw vegetables, were associated with ESBL-E faecal carriage.Conclusions
The high prevalence of ESBL-E carriage observed among peripartum women in Southeast-Asia and the identified associated factors underline the urgent need for public health measures to address antimicrobial resistance, including a 'One Health' approach.
SUBMITTER: de Lauzanne A
PROVIDER: S-EPMC9525094 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
de Lauzanne Agathe A Sreng Navin N Foucaud Elsa E Sok Touch T Chon Thida T Yem Chhaily C Hak Veasna V Heng Sothada S Soda Meng M Gouali Malika M Nadimpalli Maya M Inghammar Malin M Rabenandrasana Mamitina Alain Noah MAN Collard Jean Marc JM Vray Muriel M Hello Simon Le SL Kerleguer Alexandra A Piola Patrice P Delarocque-Astagneau Elisabeth E Guillemot Didier D Huynh Bich Tram BT Borand Laurence L
The Journal of antimicrobial chemotherapy 20220901 10
<h4>Background</h4>In Southeast-Asia, where many conditions associated with dissemination of ESBL-producing Enterobacterales (ESBL-E) in the community are met, data from the community are scarce but show high ESBL-E carriage prevalence. Maternal ESBL-E colonization is considered a risk factor for neonatal colonization, which is the first step towards developing neonatal sepsis. Despite this, ESBL-E carriage prevalence and its risk factors during pregnancy or postpartum remain undefined in Southe ...[more]