Cross-protective humoral immunity to coronaviruses from SARS coronavirus 2-naive sera of children with Kawasaki disease.

ABSTRACT:

Objectives

SARS coronavirus 2 (SARS-CoV-2)-associated multi-system inflammatory syndrome in children indicates that viruses can trigger a Kawasaki disease (KD)-like hyperinflammation. A plausible hypothesis was that coronavirus-specific 'holes' in humoral immunity could cause both diseases.

Methods

To determine whether SARS-CoV-2-naïve patients with KD have inferior humoral immunity for the novel coronavirus, sera of children with KD and control children from year 2015 to 2021 were subjected to ELISA, microwestern, and neutralization assays to evaluate the capabilities in recognizing the receptor-binding domain of SARS-CoV-2, spotting spike proteins of three respiratory syndromic coronaviruses, and blocking SARS-CoV-2 from binding to angiotensin-converting enzyme 2 receptors

SUBMITTER: Lin TY 

PROVIDER: S-EPMC9525189 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature