A comparison of advanced semi-quantitative amyloid PET analysis methods.

ABSTRACT:

Purpose

To date, there is no consensus on how to semi-quantitatively assess brain amyloid PET. Some approaches use late acquisition alone (e.g., ELBA, based on radiomic features), others integrate the early scan (e.g., TDr, which targets the area of maximum perfusion) and structural imaging (e.g., WMR, that compares kinetic behaviour of white and grey matter, or SI based on the kinetic characteristics of the grey matter alone). In this study SUVr, ELBA, TDr, WMR, and SI were compared. The latter - the most complete one - provided the reference measure for amyloid burden allowing to assess the efficacy and feasibility in clinical setting of the other approaches.

Methods

We used data from 85 patients (aged 44-87) who underwent dual time-point PET/MRI acquisitions. The correlat

SUBMITTER: Peira E 

PROVIDER: S-EPMC9525368 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature