P73 is required for vessel integrity controlling endothelial junctional dynamics through Angiomotin.

ABSTRACT: Preservation of blood vessel integrity, which is critical for normal physiology and organ function, is controlled at multiple levels, including endothelial junctions. However, the mechanism that controls the adequate assembly of endothelial cell junctions is not fully defined. Here, we uncover TAp73 transcription factor as a vascular architect that orchestrates transcriptional programs involved in cell junction establishment and developmental blood vessel morphogenesis and identify Angiomotin (AMOT) as a TAp73 direct transcriptional target. Knockdown of p73 in endothelial cells not only results in decreased Angiomotin expression and localization at intercellular junctions, but also affects its downstream function regarding Yes-associated protein (YAP) cytoplasmic sequestration upon cell-ce

SUBMITTER: Maeso-Alonso L 

PROVIDER: S-EPMC9525397 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature