Epidemiology and outcomes of primary sclerosing cholangitis: an Australian multicentre retrospective cohort study.

ABSTRACT:

Background and aims

Little is known regarding the epidemiology and outcomes of patients with primary sclerosing cholangitis (PSC) in Australia. We, therefore, evaluated the epidemiology and clinical outcomes of PSC in a large cohort of Australian patients and compared these to the general population.

Methods

We conducted a multicentre, retrospective cohort study of PSC patients at nine tertiary liver centers across three Australian states, including two liver transplant centers.

Results

A total of 413 PSC patients with 3,285 person-years of follow-up were included. Three hundred and seventy-one (90%) patients had large duct PSC and 294 (71%) had associated inflammatory bowel disease. A total of 168 (41%) patients developed cirrhosis (including 34 at the time of PSC di

SUBMITTER: Tan N 

PROVIDER: S-EPMC9525417 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature