Direct inference of Patlak parametric images in whole-body PET/CT imaging using convolutional neural networks.

ABSTRACT:

Purpose

This study proposed and investigated the feasibility of estimating Patlak-derived influx rate constant (K_i) from standardized uptake value (SUV) and/or dynamic PET image series.

Methods

Whole-body ¹⁸F-FDG dynamic PET images of 19 subjects consisting of 13 frames or passes were employed for training a residual deep learning model with SUV and/or dynamic series as input and K_i-Patlak (slope) images as output. The training and evaluation were performed using a nine-fold cross-validation scheme. Owing to the availability of SUV images acquired 60 min post-injection (20 min total acquisition time), the data sets used for the training of the models were split into two groups: "With SUV" and "Without SUV." For "With SUV" group, the model was

SUBMITTER: Zaker N 

PROVIDER: S-EPMC9525418 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature