One-step extraction and determination of 513 psychoactive substances, drugs, and their metabolites from hair by LC-MS/MS.

ABSTRACT: The emergence of new psychoactive substances on the market is a significant problem on a global scale. This type of substance in society is associated with many negative consequences, such as traffic accidents, accidents at work, rape, homicide, poisoning, or overdose deaths. The analysis of these substances in biological samples is very important for further legal action and saving lives. Therefore, laboratories face a tremendous challenge in tackling the evolving drug market. The paper describes the optimization of the analytical LC-MS/MS method to identify and determine 513 psychoactive substances in hair samples. A method of chromatographic separation was developed, and the working parameters of the mass spectrometer were selected for each analyte. The method has been validated, and th

SUBMITTER: Musial J 

PROVIDER: S-EPMC9525419 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature