A comprehensive in vitro comparison of the biological and physicochemical properties of bioactive root canal sealers.

ABSTRACT:

Objectives

To evaluate the biological and physicochemical features of bioactive root canal sealers.

Materials and methods

Human periodontal ligament fibroblasts (hPDLF) and human osteoblasts (hOB) were exposed to eluates of three bioactive root canal sealers, GuttaFlow® bioseal (GF), BioRoot™ RCS (BR), and TotalFill® BC Sealer (TF), and the epoxy resin-based sealer AH plus® (AH). Cytotoxicity and cellular inflammatory response were evaluated. The osteogenic potential was examined using human mesenchymal stem cells (hMSC). Film thickness, flowability, and pH were assessed. Root canal treatment was performed on human extracted teeth to evaluate the sealers' tightness towards bacterial penetration. The antibacterial activity against common pathogens in primary root canal infect

SUBMITTER: Wuersching SN 

PROVIDER: S-EPMC9525420 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature