A comparison of blood and brain-derived ageing and inflammation-related DNA methylation signatures and their association with microglial burdens.

ABSTRACT: Inflammation and ageing-related DNA methylation patterns in the blood have been linked to a variety of morbidities, including cognitive decline and neurodegenerative disease. However, it is unclear how these blood-based patterns relate to patterns within the brain and how each associates with central cellular profiles. In this study, we profiled DNA methylation in both the blood and in five post mortem brain regions (BA17, BA20/21, BA24, BA46 and hippocampus) in 14 individuals from the Lothian Birth Cohort 1936. Microglial burdens were additionally quantified in the same brain regions. DNA methylation signatures of five epigenetic ageing biomarkers ('epigenetic clocks'), and two inflammatory biomarkers (methylation proxies for C-reactive protein and interleukin-6) were compared across tiss

SUBMITTER: Stevenson AJ 

PROVIDER: S-EPMC9525452 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature