Impact of radiopharmaceutical therapy (¹⁷⁷Lu, ²²⁵Ac) microdistribution in a cancer-associated fibroblasts model.

ABSTRACT:

Background

The aim of this study is to elucidate the difference in absorbed dose (D_abs) patterns in radiopharmaceutical therapies between alpha emitters (²²⁵Ac) and beta emitters (¹⁷⁷Lu) when targeting cancer-associated fibroblasts (CAF) or tumor cells. Five spherical models with 3 mm diameter were created, representing spherical tumor masses that contain tumor clusters, interspersed with CAFs. The mean distance from a tumor cell to the nearest CAF (L_mean) varied throughout these models from 92 to 1030 µm. D_abs calculations were performed while selecting either CAFs or tumor cells as sources, with Convolution/Superposition with ¹⁷⁷Lu and Monte Carlo simulations (GATE) with ²²⁵Ac. Analyses were conducted wi

SUBMITTER: Tranel J 

PROVIDER: S-EPMC9525486 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature