Trilobatin rescues cognitive impairment of Alzheimer's disease by targeting HMGB1 through mediating SIRT3/SOD2 signaling pathway.

ABSTRACT: Alzheimer's disease (AD) is a progressive neurodegenerative disorder with cognitive impairment that currently is uncurable. Previous study shows that trilobatin (TLB), a naturally occurring food additive, exerts neuroprotective effect in experimental models of AD. In the present study we investigated the molecular mechanisms underlying the beneficial effect of TLB on experimental models of AD in vivo and in vitro. APP/PS1 transgenic mice were administered TLB (4, 8 mg· kg^-1 ·d^-1, i.g.) for 3 months; rats were subjected to ICV injection of Aβ_25-35, followed by administration of TLB (2.5, 5, 10 mg· kg^-1 ·d^-1, i.g.) for 14 days. We showed that TLB administration significantly and dose-dependently ameliorated the cognitive deficits in the

SUBMITTER: Gao JM 

PROVIDER: S-EPMC9525711 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature