The effect of a methadone-initiated memory reconsolidation updating procedure in opioid use disorder: A translational study.

ABSTRACT:

Background

Opioid use disorder (OUD) is a chronic relapsing psychiatric disorder. An unconditioned stimulus (US)-triggers a memory reconsolidation updating procedure (MRUP) that has been developed and demonstrated its effectiveness in decreasing relapse to cocaine and heroin in preclinical models. However, utilizations of abused drugs as the US to initiate MRUP can be problematic. We therefore designed a translational rat study and human study to evaluate the efficacy of a novel methadone-initiated MRUP.

Methods

In the rodent study, male rats underwent heroin self-administration training for 10 consecutive days, and were randomly assigned to receive saline or methadone at 10 min, 1 h or 6 h before extinction training after 28-day withdrawal. The primary outcome was operant h

SUBMITTER: Yue JL 

PROVIDER: S-EPMC9525804 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature