Agathisflavone, a natural biflavonoid that inhibits SARS-CoV-2 replication by targeting its proteases.

ABSTRACT: Despite the fast development of vaccines, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) still circulates through variants of concern (VoC) and escape the humoral immune response. SARS-CoV-2 has provoked over 200,000 deaths/months since its emergence and only a few antiviral drugs showed clinical benefit up to this moment. Thus, chemical structures endowed with anti-SARS-CoV-2 activity are important for continuous antiviral development and natural products represent a fruitful source of substances with biological activity. In the present study, agathisflavone (AGT), a biflavonoid from Anacardium occidentale was investigated as a candidate anti-SARS-CoV-2 compound. In silico and enzymatic analysis indicated that AGT may target mainly the viral main protease (M^pro

SUBMITTER: Chaves OA 

PROVIDER: S-EPMC9525951 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature