Linkage mapping reveals loci that underlie differences in Caenorhabditis elegans growth.

ABSTRACT: Growth rate and body size are complex traits that contribute to the fitness of organisms. The identification of loci that underlie differences in these traits provides insights into the genetic contributions to development. Leveraging Caenorhabditis elegans as a tractable metazoan model for quantitative genetics, we can identify genomic regions that underlie differences in growth. We measured postembryonic growth of the laboratory-adapted wild-type strain (N2) and a wild strain from Hawaii (CB4856) and found differences in body size. Using linkage mapping, we identified three distinct quantitative trait loci (QTL) on chromosomes IV, V, and X that are associated with variation in body growth. We further examined these growth-associated quantitative trait loci using chromosome substitution s

SUBMITTER: Nyaanga J 

PROVIDER: S-EPMC9526057 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature