The RNA-binding protein Swm is critical for Drosophila melanogaster intestinal progenitor cell maintenance.

ABSTRACT: The regulation of stem cell survival, self-renewal, and differentiation is critical for the maintenance of tissue homeostasis. Although the involvement of signaling pathways and transcriptional control mechanisms in stem cell regulation have been extensively investigated, the role of post-transcriptional control is still poorly understood. Here, we show that the nuclear activity of the RNA-binding protein Second Mitotic Wave Missing is critical for Drosophila melanogaster intestinal stem cells and their daughter cells, enteroblasts, to maintain their progenitor cell properties and functions. Loss of swm causes intestinal stem cells and enteroblasts to stop dividing and instead detach from the basement membrane, resulting in severe progenitor cell loss. swm loss is further characterized by

SUBMITTER: Ariyapala IS 

PROVIDER: S-EPMC9526066 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature