Fixation dynamics of beneficial alleles in prokaryotic polyploid chromosomes and plasmids.

ABSTRACT: Theoretical population genetics has been mostly developed for sexually reproducing diploid and for monoploid (haploid) organisms, focusing on eukaryotes. The evolution of bacteria and archaea is often studied by models for the allele dynamics in monoploid populations. However, many prokaryotic organisms harbor multicopy replicons-chromosomes and plasmids-and theory for the allele dynamics in populations of polyploid prokaryotes remains lacking. Here, we present a population genetics model for replicons with multiple copies in the cell. Using this model, we characterize the fixation process of a dominant beneficial mutation at 2 levels: the phenotype and the genotype. Our results show that depending on the mode of replication and segregation, the fixation of the mutant phenotype may precede

SUBMITTER: Santer M 

PROVIDER: S-EPMC9526072 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature