A transcriptional cross species map of pancreatic islet cells.

ABSTRACT:

Objective

Pancreatic islets of Langerhans secrete hormones to regulate systemic glucose levels. Emerging evidence suggests that islet cells are functionally heterogeneous to allow a fine-tuned and efficient endocrine response to physiological changes. A precise description of the molecular basis of this heterogeneity, in particular linking animal models to human islets, is an important step towards identifying the factors critical for endocrine cell function in physiological and pathophysiological conditions.

Methods

In this study, we used single-cell RNA sequencing to profile more than 50'000 endocrine cells isolated from healthy human, pig and mouse pancreatic islets and characterize transcriptional heterogeneity and evolutionary conservation of those cells across the thre

SUBMITTER: Tritschler S 

PROVIDER: S-EPMC9526148 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature