Throat microbiota alterations in patients with hereditary angioedema.

ABSTRACT:

Background

Hereditary angioedema (HAE) is a rare disease characterized by recurrent episodes of cutaneous and submucosal edema. The clinical course of HAE is heterogeneous and unpredictable. There are no reliable indicators associated with angioedema attacks and severity. Throat microbiota plays vital roles in the maintenance of human health, while its association with HAE is barely understood. Therefore, this study aimed to investigate the alteration of throat microbiota and its correlation with attacks severity in HAE patients.

Methods

Throat swab samples were collected from HAE patients and their healthy family members, and then subjected to 16S rRNA sequencing. Alpha and beta diversity were used to examine the diversity and structure of bacterial communities. The relativ

SUBMITTER: Wang X 

PROVIDER: S-EPMC9526235 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature