Identification of molecular subtypes based on inflammatory response in lower-grade glioma.

ABSTRACT:

Background

Inflammatory response is an important characteristic affecting prognosis and therapeutic response in lower-grade glioma (LGG). However, the molecular subtypes based on inflammatory response are still under exploitation.

Methods

The RNA sequencing, somatic mutation, and corresponding clinical data from 1205 LGG patients were obtained from the TCGA, CGGA, and Rembrandt cohorts. Consensus clustering was performed to identify molecular subtypes associated with inflammation. Prognosis, clinicopathologic features, immune cell infiltration, and somatic mutation profile were compared among these inflammation-associated subtypes.

Results

Our results demonstrate that LGG could be categorized into inflammation-, low, -mid, and -high subtypes with distinct clinicopatho

SUBMITTER: Lin W 

PROVIDER: S-EPMC9526248 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature