A unique, newly discovered four-member protein family involved in extracellular fatty acid binding in Yarrowia lipolytica.

ABSTRACT:

Background

Yarrowia lipolytica, a nonconventional oleaginous yeast species, has attracted attention due to its high lipid degradation and accumulation capacities. Y. lipolytica is used as a chassis for the production of usual and unusual lipids and lipid derivatives. While the genes involved in the intracellular transport and activation of fatty acids in different cellular compartments have been characterized, no genes involved in fatty acid transport from the extracellular medium into the cell have been identified thus far. In this study, we identified secreted proteins involved in extracellular fatty acid binding.

Results

Recent analysis of the Y. lipolytica secretome led to the identification of a multigene family that encodes four secreted proteins, preliminarily named U

SUBMITTER: Onesime D 

PROVIDER: S-EPMC9526294 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature