Altered methylation pattern in EXOC4 is associated with stroke outcome: an epigenome-wide association study.

ABSTRACT:

Background and purpose

The neurological course after stroke is highly variable and is determined by demographic, clinical and genetic factors. However, other heritable factors such as epigenetic DNA methylation could play a role in neurological changes after stroke.

Methods

We performed a three-stage epigenome-wide association study to evaluate DNA methylation associated with the difference between the National Institutes of Health Stroke Scale (NIHSS) at baseline and at discharge (ΔNIHSS) in ischaemic stroke patients. DNA methylation data in the Discovery (n = 643) and Replication (n = 62) Cohorts were interrogated with the 450 K and EPIC BeadChip. Nominal CpG sites from the Discovery (p value < 10^-06) were also evaluated in a meta-analysis of the Discovery and R

SUBMITTER: Cullell N 

PROVIDER: S-EPMC9526296 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature