The Notch Signaling Pathway Contributes to Angiogenesis and Tumor Immunity in Breast Cancer.

ABSTRACT: Breast cancer in women is the first leading tumor in terms of incidence worldwide. Some subtypes of BC lack distinct molecular targets and exhibit therapeutic resistance; these patients have a poor prognosis. Thus, the search for new molecular targets is an ongoing challenge for BC therapy. The Notch signaling pathway is found in both vertebrates and invertebrates, and it is a highly conserved in the evolution of the species, controlling cellular fates such as death, proliferation, and differentiation. Numerous studies have shown that improper activation of Notch signaling may lead to excessive cell proliferation and cancer, with tumor-promoting and tumor-suppressive effects in various carcinomas. Thus, inhibitors of Notch signaling are actively being investigated for the treatment of vari

SUBMITTER: Jiang N 

PROVIDER: S-EPMC9526507 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature