Role of Carbon Monoxide in Oxidative Stress-Induced Senescence in Human Bronchial Epithelium.

ABSTRACT: Prolonged or excessive stimulation from inhaled toxins may cause oxidative stress and DNA damage that can lead to stress-induced senescence in epithelial cells, which can contribute to several airway diseases. Mounting evidence has shown carbon monoxide (CO) confers cytoprotective effects. We investigated the effects of CO on oxidative stress-induced senescence in human airway epithelium and elucidated the underlying molecular mechanisms. Here, CO pretreatment reduced H₂O₂-mediated increases in total reactive oxygen species (ROS) production and mitochondrial superoxide in a human bronchial epithelial cell line (BEAS-2B). H₂O₂ treatment triggered a premature senescence-like phenotype with enlarged and flattened cell morphology accompanied by incre

SUBMITTER: Cai MY 

PROVIDER: S-EPMC9526622 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature