Peripheral Transplantation of Mesenchymal Stem Cells at Sepsis Convalescence Improves Cognitive Function of Sepsis Surviving Mice.

ABSTRACT:

Objective

To investigate the effects of peripheral transplantation of mesenchymal stem cells (MSCs) at sepsis convalescence on post-sepsis cognitive function and underlying mechanisms in mice.

Methods

Sepsis was induced by cecal ligation and puncture (CLP) in mice. Bone marrow-derived MSCs from mice were cultured and injected via tail vein on the 8^th day after CLP. Cognitive function was detected in open field, novel object recognition task, and delayed matching-to-place water maze task during 10-26 days after CLP. Neuroinflammation, neurogenesis, and peripheral inflammation were detected on the 12^th and 31^th days after CLP. MSCs tracing was detected during 8-10 days after CLP.

Results

Transplanted MSCs were located at peripheral organ

SUBMITTER: Tan L 

PROVIDER: S-EPMC9526624 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature