Taohong Siwu Decoction Promotes Osteo-Angiogenesis in Fractures by Regulating the HIF-1α Signaling Pathway.

ABSTRACT:

Background

Vascular damage is a major consequence of bone fracture. Taohong Siwu decoction (TSD) can raise the expression of vascular endothelial growth factor (VEGF) in fracture healing. However, its molecular mechanism in promoting angiogenesis is still unknown. The aim of this study was to investigate the potential mechanisms of TSD in the regulation of osteo-angiogenesis in fracture healing.

Methods

A rat tibial fracture model was established. After low- (4.5 g·kg^-1), medium- (9 g·kg^-1), and high-dose TSD (18 g·kg^-1) and panax notoginsenoside (25 mg kg^-1) treatment, hematoxylin-eosin staining was employed to visualize pathological changes in bone tissues. The levels of cytokines (interleukin (IL)-2, tumor necrosis factor-α</

SUBMITTER: Tang Z 

PROVIDER: S-EPMC9526655 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature