Advanced Acral Melanoma Therapies: Current Status and Future Directions.

ABSTRACT:

Opinion statement

Melanoma is one of the deadliest malignancies. Its incidence has been significantly increasing in most countries in recent decades. Acral melanoma (AM), a peculiar subgroup of melanoma occurring on the palms, soles, and nails, is the main subtype of melanoma in people of color and is extremely rare in Caucasians. Although great progress has been made in melanoma treatment in recent years, patients with AM have shown limited benefit from current therapies and thus consequently have worse overall survival rates. Achieving durable therapeutic responses in this high-risk melanoma subtype represents one of the greatest challenges in the field. The frequency of BRAF mutations in AM is much lower than that in cutaneous melanoma, which prevents most AM patients from recei

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC9526689 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature