Energy landscape reshaped by strain-specific mutations underlies epistasis in NS1 evolution of influenza A virus.
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ABSTRACT:
SUBMITTER: Kim I
PROVIDER: S-EPMC9526705 | biostudies-literature | 2022 Oct
REPOSITORIES: biostudies-literature
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Energy landscape reshaped by strain-specific mutations underlies epistasis in NS1 evolution of influenza A virus.
Kim Iktae I Dubrow Alyssa A Zuniga Bryan B Zhao Baoyu B Sherer Noah N Bastiray Abhishek A Li Pingwei P Cho Jae-Hyun JH
Nature communications 20221001 1
Elucidating how individual mutations affect the protein energy landscape is crucial for understanding how proteins evolve. However, predicting mutational effects remains challenging because of epistasis-the nonadditive interactions between mutations. Here, we investigate the biophysical mechanism of strain-specific epistasis in the nonstructural protein 1 (NS1) of influenza A viruses (IAVs). We integrate structural, kinetic, thermodynamic, and conformational dynamics analyses of four NS1s of inf ...[more]
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