Progression of prostate cancer reprograms MYC-mediated lipid metabolism via lysine methyltransferase 2A.

ABSTRACT:

Background

The activities of MYC, the androgen receptor, and its associated pioneer factors demonstrate substantial reprogramming between early and advanced prostate cancer. Although previous studies have shown a shift in cellular metabolic requirements associated with prostate cancer progression, the epigenetic regulation of these processes is incompletely described. Here, we have integrated chromatin immunoprecipitation sequencing (ChIP-seq) and whole-transcriptome sequencing to identify novel regulators of metabolism in advanced prostate tumors characterized by elevated MYC activity.

Results

Using ChIP-seq against MYC, HOXB13, and AR in LNCaP cells, we observed redistribution of co-bound sites suggestive of differential KMT2A activity as a function of MYC expression. In a

SUBMITTER: Whitlock NC 

PROVIDER: S-EPMC9526773 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature