CAMP signaling factors regulate carbon catabolite repression of hemicellulase genes in Aspergillus nidulans.

ABSTRACT: Carbon catabolite repression (CCR) enables preferential utilization of easily metabolizable carbon sources, implying the presence of mechanisms to ensure discriminatory gene repression depending on the ambient carbon sources. However, the mechanisms for such hierarchical repression are not precisely understood. In this report, we examined how deletion of pkaA and ganB, which encode cAMP signaling factors, and creA, which encodes a well-characterized repressor of CCR, affects CCR of hemicellulase genes in the filamentous fungus Aspergillus nidulans. β-Xylanase production increased not only in ΔcreA but also in ΔpkaA and ΔganB, with the highest level observed in their double deletants, irrespective of the presence or absence of D-glucose. Expression of the β-xylanase genes in the presence of

SUBMITTER: Kunitake E 

PROVIDER: S-EPMC9526778 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature